10/03/08| 10/10/08 | Appomattox County
| Randolph-Henry Henry (Roanoke, VA) 49-22 21 | 10/03/08 Auburn
| Narrows Halifax County (South Boston, VA) 13-36 35 |
10/03/08 | 10/10/08 | Bassett
| Patrick Craig County (New Castle, VA) 24-25 18 | 10/03/08
| Bath County Riverheads (Hot Springs, VA) | 21-44 46 |
10/03/08 | 10/10/08 | Blacksburg
| Northside Gilbert (WV) 28-25 10/03/080 | Bluestone
| Central Lunenburg Fort Chiswell (Max Meadows, VA) | 20-47 33 |
10/03/08 | 10/10/08 |
| Buckingham Liberty County (Bedford, VA) | Manassas Park 14 |
| Brookville (Lynchburg, VA) | 24-14 36 |
10/03/08 | 10/10/08 | Chatham
| Eastern Montgomery (Elliston, VA) | Altavista 26 |
| Auburn (Riner, VA) 15-32 0 |
10/03/08 | 10/10/08 | Christiansburg
| Jefferson Forest (Jefferson, VA) | Radford 6 |
| Amherst County (Amherst, VA) 20-13 35 |
10/03/08 | 10/10/08 | Covington
| Holston (Damascus, VA) | Buffalo Gap 13 |
| Wythe (Wytheville, VA) 6-49 31 |
10/03/08 | 10/10/08 |
| E.C. Marion Glass (VA) | Forest 15 |
| Carroll County Park (Hillsville, VA) | 10-7 13 |
10/03/08 | 10/10/08 | Fishburne Military
| Radford (VA) | Covenant 35 |
| Giles (Pearisburg, VA) 6-62 28 |
10/03/08 | 10/10/08 | George
| Hidden Washington Valley (Roanoke, VA) | Franklin 16 |
| Pulaski County (Dublin, VA) | 26-28 28 |
10/03/08 | 10/10/08 |
| Glenvar (Salem, VA) | Craig 6 |
| Floyd County (Floyd, VA) | 48-6 35 |
10/03/08 | 10/10/08 | Harrisonburg
| Fleming (Roanoke, VA) | Rockbridge 7 |
| Franklin County (Rocky Mount, VA) 10-35 6 |
10/03/08 | 10/10/08 | Jefferson
| Blacksburg Forest (VA) | Brookville 28 |
| Cave Spring (Roanoke, VA) | 7-19 14 |
10/03/08 | 10/10/08 | Lebanon
| Spotswood (Penn Laird, VA) | Giles 14 |
| Rockbridge County (Lexington, VA) 7-11 21 |
10/03/08 | 10/10/08 | Liberty
| Christiansburg (VA) | Heritage 0 |
| Salem (VA) 32-14 25 |
10/03/08 | 10/10/08 | Liberty
| Rustburg Christian (VA) | St. Mary's40 |
| Alleghany Ryken,(Covington, MD VA) | 65-6 34 |
10/03/08 | 10/10/08 | Lord Botetourt
| Pulaski James County River (Buchanan, VA) | 6-40 35 | 10/03/08
| Nelson Covington County Gretna (VA) | 38-41 0 |
10/03/08 | 10/10/08 | North Cross
| Campbell (Naruna, VA) Fuqua 28 |
| Altavista Combined School (Altavista, VA) 55-0 3 |
10/03/08 | 10/10/08 | Parry McCluer
| Martinsville (VA) | East Montgomery 28 |
| Magna Vista (Ridgeway, VA) | 26-38 14 |
10/03/08 | 10/10/08 | Prince Edward
| Grayson County (Independence, VA) | Brunswick 28 |
| Galax (VA) | 29-28 30 |
10/03/08 | 10/10/08 | Rustburg
| Amherst Appomattox County (Appomattox, VA) | 8-41 32 | 10/03/08
| Staunton Dan River Alleghany County (Ringgold, VA) | 7-28 27 |
10/03/08 | 10/10/08 | Turner Ashby
| Stuarts Draft Chatham (VA) 28-7 0 | 10/03/08
| Virginia Episcopal Gretna School (VA) | St. Anne's-Belfield 35-56 69 |
10/03/08 | 10/10/08 | Waynesboro
| Washington (Danville, VA) Robert E. Lee 0-47 28 | 10/03/08
| William Glass Byrd Cave(Lynchburg, Spring VA) | 21-16 14 |
10/03/08 | 10/10/08 | William
| Byrd Campbell (Vinton, VA) Dan River 28 |
| Patrick County (Stuart, VA) | 43-7 20 |
10/03/08 | 10/10/08 | Wilson Memorial
| Bassett (VA) | James River 27 |
| Tunstall (Dry Fork, VA) | 21-6 6 |